The use of CBD has increased greatly, so are the concerns regarding its use. A lot of CBD products are now available in the market and a large number of people are now using it on a daily basis. However, there are still arguments going on about the safety of this hemp-derived compound. The FDA or any other authorized agencies have not yet approved the use of CBD products. It adds to the concerns that exist regarding this compound.
Even though CBD is not found to create severe side effects, it still causes certain problems in some people. The commonly found CBD side effects include diarrhea, fatigue, changes in weight and appetite, etc. Another prominent side effect of this compound is its interaction with other drugs that can lead to liver damage. Hence, we list some CBD drug interactions for helping you to know whether you can use this compound with a specific drug.
Types Of CBD Drug Interactions
CBD can interact with different types of drugs. Following are some medications that are found to interact with CBD and cause liver toxicity:
- Antidepressants (like Prozac or fluoxetine)
- Medications that result in drowsiness (benzodiazepines, antipsychotics)
- Macrolide antibiotics (clarithromycin, erythromycin)
- Heart medications (including some calcium channel blockers)
A large number of drugs are broken down by a family of liver enzymes known as CYP450. CBD might inhibit some of the enzymes in this family, hence, it can slow down the breakdown of certain drugs. This could increase the side effects caused by such drugs. In some other cases, CBD may stimulate certain enzymes in the same family, this will result in the speeding up of drug breakdown. So the effect of these drugs may diminish.
Proof Of CBD Drug Interactions
The trustable evidence for proving the CBD drug interactions come from studies conducted using the FDA-approved CBD medication called Epidiolex. This medicine, which is used to treat epilepsy, interacts with blood and makes it thinner, thereby increasing the blood levels. This raises the risk of bleeding. Epidiolex also interacts with some other medications used for the treatment of epilepsy.
Who Are At Higher Risk Of CBD Drug Interactions?
Older people are at higher risk of CBD drug interactions. As we age, our livers will become slow in eliminating drugs from our body. Also, older people might be taking different tablets for various diseases, hence, it is very likely for them to have drug interactions because of CBD use. In addition to this, people who already have liver damages are also at higher risk of CBD drug interactions.